Biphasic Scaffolds Functionalized with Piezoelectric Nanozymes for Osteochondral Defect Regeneration
redox cycle. This nanozyme is incorporated into GelMA/Alginate hydrogel to form the cartilage layer, whereas a GelMA/Alginate/β-TCP composite is extrusion-printed as the subchondral bone layer. Under ultrasound stimulation in vitro, the cartilage layer significantly boosts BMSC chondrogenesis; meanwhile, the β-TCP bone layer supports osteogenic differentiation. The biphasic scaffold achieves superior defect filling, hyaline-like cartilage regeneration, and osteochondral interface reconstruction in vivo. In general, this biphasic scaffold that synergizes piezoelectrically mediated bioelectrical cues and ROS modulation offers a promising strategy for achieving durable osteochondral regeneration.
Authors
- Wenxing Chen (ORCID: https://orcid.org/0000-0001-9669-4358)
- Chao Tong (ORCID: https://orcid.org/0000-0002-8134-0263)
- Haibin Ding
- Yingkun Hu (ORCID: https://orcid.org/0000-0002-4483-5072)
- Xiaoshan Gong (ORCID: https://orcid.org/0009-0005-8690-4696)
- Jinbao Li (ORCID: https://orcid.org/0000-0003-0912-3528)
- Yusheng Yang
- Shiyi Dai
- Chunrong Zhao
- Yan Fang
Institutions
- Hebei Medical University (CN)
- Army Medical University (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Third Hospital of Hebei Medical University (CN)
- Daping Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Advanced Healthcare Materials
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/adhm.202600012
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00