Lipidation of a nuclear localization sequence enhances broad-spectrum antimicrobial activity: synthesis, characterization, and in silico analysis

(MIC = 6.96 µM), while LP-3 and LP-4 demonstrated moderate, broad-spectrum activity. Computational analyses indicated favorable target interactions, though they did not fully correlate with experimental results. LP-4 and LP-5 showed the smallest HOMO-LUMO gaps (∼0.111-0.112 eV), suggesting higher electronic reactivity. Overall, lipidation of PKKKRKV is a promising strategy for developing antimicrobial agents. Chain length and saturation significantly influence activity, with LP-5 emerging as the most promising broad-spectrum candidate. Further studies are required to validate mechanisms and assess toxicity..

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Publication Details

Journal
Artificial Cells Nanomedicine and Biotechnology
Published
2026-03-31
DOI
https://doi.org/10.1080/21691401.2026.2649071
Primary Topic
Antimicrobial Peptides and Activities
Type
article
Field-Weighted Citation Impact
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article

Lipidation of a nuclear localization sequence enhances broad-spectrum antimicrobial activity: synthesis, characterization, and in silico analysis

Muhamad Imam Muhajir, Reza Aditama, Taufik Muhammad Fakih, Tarwadi Tarwadi et al.
Artificial Cells Nanomedicine and Biotechnology
Antimicrobial Peptides and Activities
article

Lipidation of a nuclear localization sequence enhances broad-spectrum antimicrobial activity: synthesis, characterization, and in silico analysis

Muhamad Imam Muhajir, Reza Aditama, Taufik Muhammad Fakih, Tarwadi Tarwadi, Ace Tatang Hidayat, Rani Maharani, Anggun Fuji Rizqiyani, Doddy Irawan Setyo Utomo
article en

Abstract

(MIC = 6.96 µM), while LP-3 and LP-4 demonstrated moderate, broad-spectrum activity. Computational analyses indicated favorable target interactions, though they did not fully correlate with experimental results. LP-4 and LP-5 showed the smallest HOMO-LUMO gaps (∼0.111-0.112 eV), suggesting higher electronic reactivity. Overall, lipidation of PKKKRKV is a promising strategy for developing antimicrobial agents. Chain length and saturation significantly influence activity, with LP-5 emerging as the most promising broad-spectrum candidate. Further studies are required to validate mechanisms and assess toxicity..

Artificial Cells Nanomedicine and BiotechnologyVol. 54(1)
Bandung Institute of Technology (ID), University of Indonesia (ID), Institut de Recherche Vaccinale (FR), Bandung Islamic University (ID), Padjadjaran University (ID)
Industry, innovation and infrastructure
Openalex Percentile: Top 36%
Antimicrobial Peptides and Activities
DOIOpen Access PDFOpenAlex
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Lipidation of a nuclear localization sequence enhances broad-spectrum antimicrobial activity: synthesis, characterization, and in silico analysis — Muhamad Imam Muhajir, Reza Aditama, et al. · Artificial Cells Nanomedicine and Biotechnology (2026) | TGRS Research Map | TGRS