Intercellular communication is a heritable dimension of human tissue architecture
) organized into convergent pathway families-neurexin-neuroligin synaptic signaling in bipolar disorder, vascular adhesion in cardiovascular traits, and lipoprotein-clearance pathways in liver. Most edge genes are absent from standard gene-level prioritization, supporting intercellular communication as a complementary dimension of genetic architecture.
Authors
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Chen Yang
- Jun Chen
Institutions
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Texas A&M University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-31
- DOI
- https://doi.org/10.64898/2026.03.29.715138
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Center for Individualized Medicine, Mayo Clinic