Convergence of external and internal stressors on a stress-responsive enhancer of the <i>Sonic hedgehog</i> gene to induce hair disorders

gene expression, and provide a plausible strategy for therapeutic intervention. Our results establish a paradigm of how stress perturbs organ growth and regeneration through the regulation of key intrinsic morphogenetic factors.

Authors

Zhicao Yue (ORCID: https://orcid.org/0000-0001-5729-3842)
Z. Chen
Zhiyong Huang (ORCID: https://orcid.org/0000-0001-5374-3973)
Xiaoqi Chen (ORCID: https://orcid.org/0000-0003-3227-4607)
Yan Zhang (ORCID: https://orcid.org/0000-0001-6197-7008)
KaiBin Yang
HouDong Zhou
Ralf Paus

Institutions

Fujian Normal University (CN)
Fujian University of Traditional Chinese Medicine (CN)
University of Miami (US)
Clinical Research Center for Hair and Skin Science (DE)
Cancer Genetics (United States) (US)

Publication Details

Journal: Proceedings of the National Academy of Sciences
Published: 2026-03-31
DOI: https://doi.org/10.1073/pnas.2529339123
Primary Topic: Hair Growth and Disorders
Type: article
Field-Weighted Citation Impact: 0.00

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article

Convergence of external and internal stressors on a stress-responsive enhancer of the Sonic hedgehog gene to induce hair disorders

Zhicao Yue, Z. Chen, Zhiyong Huang, Xiaoqi Chen et al.

Mar 31, 2026

Proceedings of the National Academy of Sciences

Hair Growth and Disorders

article

Convergence of external and internal stressors on a stress-responsive enhancer of the Sonic hedgehog gene to induce hair disorders

Zhicao Yue, Z. Chen, Zhiyong Huang, Xiaoqi Chen, Yan Zhang, KaiBin Yang, HouDong Zhou, Ralf Paus

March 31, 2026article en

Abstract

gene expression, and provide a plausible strategy for therapeutic intervention. Our results establish a paradigm of how stress perturbs organ growth and regeneration through the regulation of key intrinsic morphogenetic factors.

Proceedings of the National Academy of SciencesVol. 123(14)

Fujian Normal University (CN), Fujian University of Traditional Chinese Medicine (CN), University of Miami (US), Clinical Research Center for Hair and Skin Science (DE), Cancer Genetics (United States) (US)

Openalex Percentile: Top 36%

Hair Growth and Disorders

DOI Open Access PDF OpenAlex

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Convergence of external and internal stressors on a stress-responsive enhancer of the <i>Sonic hedgehog</i> gene to induce hair disorders — Zhicao Yue, Z. Chen, et al. · Proceedings of the National Academy of Sciences (2026) | TGRS Research Map | TGRS