In Vivo Trypanocidal Activity of the Drug Disulfiram Combined with Benznidazole
strains. DS was tested alone or in combination with BZ at different doses for 20 consecutive days during the acute or chronic phase of the infection. Parasitological cure, inflammation in the heart and colon, and serum nitric oxide levels were assessed; in Y strain-infected animals, liver oxidative damage was also evaluated, while in VL-10-infected animals, parasitemia, survival rate, and collagen formation were analyzed. The combination of BZ + DS (100 mg/kg +50 mg/kg) induced 50% parasitological cure, reduced cardiac inflammation in Y strain infection, and decreased cardiac fibrosis in VL-10 strain infection. However, the results suggest a limited adjuvant effect of disulfiram, warranting further investigation.
Authors
- Brian Alejandro Suarez Mantilla
- Thays Helena Chaves Duarte
- Aline Tonhela Ferraz (ORCID: https://orcid.org/0000-0001-5772-9722)
- Paula Melo de Abreu Vieira (ORCID: https://orcid.org/0000-0001-7033-7686)
- Cláudia Martins Carneiro (ORCID: https://orcid.org/0000-0002-6002-857X)
- Flávia de Souza Marques
- Viviane Flores Xavier
- Lucas Resende Dutra Sousa (ORCID: https://orcid.org/0000-0003-2408-3448)
- Fernanda Caetano Camini
- Kátia da Silva Fonseca
- Daniela Caldeira Costa Calsavara
- Ariel Mariano Silber
Institutions
- Universidade Federal de Ouro Preto (BR)
- Exact Sciences (United States) (US)
- Institute of Parasitology (CZ)
Publication Details
- Journal
- ACS Infectious Diseases
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1021/acsinfecdis.5c00936
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Universidade Federal de Ouro Preto