Redox-driven speciation and colloid formation contribute the in vivo chemistry and organ deposition of Astatine-211
BACKGROUND: At remain insufficiently understood, limiting rational radiopharmaceutical design. RESULTS: under physiological conditions and predicted the predominance of oxidized and hydrolyzed species. CONCLUSIONS: At-based radiopharmaceuticals.
Authors
- Xiaoxu Dong
- Kaiqi Zhang (ORCID: https://orcid.org/0009-0009-8614-7751)
- Qingnuan Li (ORCID: https://orcid.org/0000-0003-1629-2274)
- Mumei Chen
- Huawei Cai
- Xiaozheng Zhang
- Lan Zhang
- Jiajun Liu
- Xiao Li
- Fengling Shan
- Shuai Xue
- Jiaojiao Li
Institutions
- Chinese Academy of Sciences (CN)
- Sichuan University (CN)
- Fudan University (CN)
- Ruijin Hospital (CN)
- West China Hospital of Sichuan University (CN)
- Shanghai Institute of Applied Physics (CN)
- Pudong Medical Center (CN)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1186/s41181-026-00441-3
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China