Systemic Treatment of Thyroid Cancer: ASCO Guideline
. PURPOSE: To provide evidence-based recommendations on the use of systemic therapy in different types of thyroid cancers. METHODS: The American Society of Clinical Oncology convened a multidisciplinary Expert Panel to evaluate the evidence and formulate recommendations. The literature search included studies published between January 1, 2000, and November 5, 2025, and comprised systematic reviews, meta-analyses, randomized controlled trials, and observational studies. Outcomes of interest included overall survival, disease-free survival, and safety. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS: A total of 66 publications were identified to inform the evidence base for this guideline. RECOMMENDATIONS: Evidence-based recommendations address the use of systemic therapy in patients with well-differentiated, differentiated high-grade or poorly differentiated, anaplastic, and medullary thyroid cancer.Additional information is available at https://ascopubs.org/topics/asco-guidelines/head-neck-cancer.
Authors
- Lova Sun (ORCID: https://orcid.org/0000-0002-5015-2964)
- Guilherme Harada (ORCID: https://orcid.org/0000-0003-4012-3251)
- Erik Blomain (ORCID: https://orcid.org/0000-0001-8820-2384)
- Francis P. Worden (ORCID: https://orcid.org/0000-0002-6632-4951)
- Nabil F. Saba (ORCID: https://orcid.org/0000-0003-4972-1477)
- Salem I. Noureldine (ORCID: https://orcid.org/0000-0002-4442-8944)
- Beth M. Beadle (ORCID: https://orcid.org/0000-0001-5497-2831)
- Thomas J. Galloway (ORCID: https://orcid.org/0000-0002-5730-2099)
- Nofisat Ismaila (ORCID: https://orcid.org/0000-0003-2074-1896)
- Joe Scharpf
- Neil S. Akhave
- D. Adkins
- D P Li
- Mei Tang
- Maria E. Cabanillas
- Nishant Agrawal
- Lori Wirth
- Dan P. Zandberg
Institutions
- Fox Chase Cancer Center (US)
- American Society of Clinical Oncology (US)
- Cleveland Clinic (US)
- The University of Texas MD Anderson Cancer Center (US)
- Emory University (US)
- George Washington University (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Massachusetts General Hospital (US)
- City of Hope (US)
- Penn Center for AIDS Research (US)
- UPMC Hillman Cancer Center (US)
- University of Pennsylvania Health System (US)
- Hospital Sírio-Libanês (BR)
- Towson University (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1200/jco-26-00235
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00