Harnessing AlphaFold3 to elucidate BBSome structure and protein partners
mutation destabilizes the complex, and uncovers novel contacts with various receptors including those involved in metabolic regulation. These findings provide a predictive framework linking BBSome structure to ciliary signaling and metabolic regulation in Bardet-Biedl syndrome.
Authors
- Kamal Rahmouni (ORCID: https://orcid.org/0000-0001-5136-6748)
- Kai Vorhies (ORCID: https://orcid.org/0000-0002-8673-0703)
- Younes Rouabhi
- Deng-Fu Guo
- Mallory Tollefson
Institutions
- University of Iowa (US)
- Iowa City VA Health Care System (US)
Publication Details
- Journal
- American Journal of Physiology-Cell Physiology
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1152/ajpcell.00804.2025
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health