Development and validation of a risk prediction model for prostate cancer integrating quantitative MRI and clinical data

Objectives: To develop and validate a predictive model for prostate cancer (PCa)by integrating quantitative MRI and clinical data. Methods: ), synthetic relaxometry (MAGiC), iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation (IDEAL-IQ), and amide proton transfer (APT) sequences. Based on pathological results, patients were stratified into PCa group (n=140) and Non-PCa group (n=150). All quantitative parameters derived from multimodal MRI were measured independently by a dedicated team of radiologists, and their reproducibility was assessed through intra-class correlation coefficients (ICCs). Differences in all MRI quantitative parameters and clinical data between the groups were compared. All patients were randomly divided into a training group (203 cases) and a validation group (87 cases) at a ratio of 7:3. The Least Absolute Shrinkage and Selection Operator (LASSO) and Logistic regression were used to screen independent predictive parameters for PCa, constructing a predictive model, internal validation and bootstrap validation were performed on the model. The model was evaluated using receiver operating characteristic curves (ROC), goodness-of-fit tests (Hosmer-Lemeshow statistic), calibration curves, and decision curve analysis (DCA), and presented in the form of nomograms. Results: > 0.05), and a substantial net benefit on decision curve analysis. Conclusion: The prediction model based on quantitative MRI and clinical parameters has good performance in discrimination, stability, consistency and clinical applicability. Compared to existing diagnostic models, it offers distinct advantages in data objectivity, reproducibility, non-invasiveness, cost-effectiveness, and operational simplicity.