Comparison of [18F]DPA-814 with [18F]DPA-714 for TSPO Imaging in an Experimental Model

PURPOSE: F]DPA-714 for inflammation imaging in SARS-CoV-2-infected macaques in a longitudinal setting. PROCEDURES: F]DPA-814. Four additional macaques were infected with SARS-CoV-2 and monitored for 12 months using whole-body PET-computed tomography (CT) with both tracers. Baseline scans were compared to PET-CTs obtained at 4, 9 and 16 days and at 6 and 12 months post-infection, covering the head, thorax and abdomen. Tracer uptake was assessed in several organs. RESULTS: F]DPA-714. In the brain, the tracers also displayed divergent uptake patterns despite comparable TSPO levels across animals and regions. CONCLUSIONS: F]DPA-714 for lung and brain imaging, and further studies are required to evaluate its suitability in other anatomical regions.

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Journal
Molecular Imaging and Biology
Published
2026-04-01
DOI
https://doi.org/10.1007/s11307-026-02094-9
Primary Topic
Pharmacological Receptor Mechanisms and Effects
Type
article
Field-Weighted Citation Impact
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article

Comparison of [18F]DPA-814 with [18F]DPA-714 for TSPO Imaging in an Experimental Model

Erik Nutma, Wissam Beaino, Jinte Middeldorp, Julia van der Bie et al.
Molecular Imaging and Biology
Pharmacological Receptor Mechanisms and Effects
article

Comparison of [18F]DPA-814 with [18F]DPA-714 for TSPO Imaging in an Experimental Model

Erik Nutma, Wissam Beaino, Jinte Middeldorp, Julia van der Bie, A. D. Windhorst, M. Kassiou, E. J. Verschoor, J. A. M. Langermans, J. J. Danon, J. Bakker, M. A. Stammes
article en

Abstract

PURPOSE: F]DPA-714 for inflammation imaging in SARS-CoV-2-infected macaques in a longitudinal setting. PROCEDURES: F]DPA-814. Four additional macaques were infected with SARS-CoV-2 and monitored for 12 months using whole-body PET-computed tomography (CT) with both tracers. Baseline scans were compared to PET-CTs obtained at 4, 9 and 16 days and at 6 and 12 months post-infection, covering the head, thorax and abdomen. Tracer uptake was assessed in several organs. RESULTS: F]DPA-714. In the brain, the tracers also displayed divergent uptake patterns despite comparable TSPO levels across animals and regions. CONCLUSIONS: F]DPA-714 for lung and brain imaging, and further studies are required to evaluate its suitability in other anatomical regions.

Molecular Imaging and Biology
The University of Sydney (AU), Utrecht University (NL), Biomedical Primate Research Centre (NL), Amsterdam Neuroscience (NL), Amsterdam University Medical Centers (NL), Vrije Universiteit Amsterdam (NL)
Good health and well-being
Openalex Percentile: Top 38%
Pharmacological Receptor Mechanisms and Effects
DOIOpen Access PDFOpenAlex
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Comparison of [18F]DPA-814 with [18F]DPA-714 for TSPO Imaging in an Experimental Model — Erik Nutma, Wissam Beaino, et al. · Molecular Imaging and Biology (2026) | TGRS Research Map | TGRS