Intrinsic Diversity in Odor-Evoked Calcium Rises across <i>Drosophila</i> Olfactory Neurons
ORN types of either sex. Despite comparable spike rates, calcium signals can differ by more than 10-fold. Within each ORN, calcium scaled linearly with spiking, yet the slope varied markedly across neuron types. Mechanistically, calcium gain was intrinsic to ORN type, independent of receptor identity, and differentially regulated in distinct ORNs by internal calcium store and voltage-dependent calcium entry. These findings reveal striking heterogeneity in odor-evoked calcium gain, with implications for how individual ORNs interpret odor activation to differentially engage activity-dependent processes and plasticity.
Authors
- Shiuan‐Tze Wu (ORCID: https://orcid.org/0000-0002-8445-1882)
- Renny Ng (ORCID: https://orcid.org/0000-0003-3681-7269)
- Chih‐Ying Su (ORCID: https://orcid.org/0000-0002-0005-1890)
- Yiyi Xiao (肖奕艺)
Institutions
- University of California San Diego (US)
Publication Details
- Journal
- Journal of Neuroscience
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1523/jneurosci.2132-25.2026
- Primary Topic
- Neurobiology and Insect Physiology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- California Institute of Technology
- Achievement Rewards for College Scientists Foundation
- National Institutes of Health
- University of California, San Diego
- National Institute on Deafness and Other Communication Disorders
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- National Institute of Neurological Disorders and Stroke
- School of Medicine, University of California, San Diego