Dual-trigger model of CD20 escape: NONO regulation and cryptic splicing induced by transcript overload in pediatric B-ALL
Introduction: , a non-POU domain-containing octamer-binding protein implicated in several cancers, regulates CD20 surface expression. Methods: was used to examine its effect on splicing. Results: mRNA. Discussion: are associated with CD20 heterogeneity in pediatric B-ALL. These observations may contribute to understanding variability in CD20 expression and antigen availability in pediatric B-ALL.
Authors
- Sebastian Maxeiner
- Claudia Paret (ORCID: https://orcid.org/0000-0002-9094-1634)
- Francesca Alt
- Nicole Ziegler (ORCID: https://orcid.org/0000-0002-8327-8619)
- Jörg Faber
- Moein Kermani
- Julian König
Institutions
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- University of Würzburg (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- German Cancer Society (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3389/fimmu.2026.1763413
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00