Chronology of tRNA structural dynamics prior to and during interaction with a pseudouridine synthase
that is initially unmodified more gradually approached the ensemble of structures that were attained rapidly by pre-modified tRNA. Thus, Pus4 both catalyzes a lasting chemical change on tRNA and remodels it over time after catalysis, perhaps to promote subsequent steps of tRNA maturation.
Authors
- Abigail L Vaaler (ORCID: https://orcid.org/0000-0001-6096-9428)
- Julia R. Widom (ORCID: https://orcid.org/0000-0002-6357-2749)
- Emily Dennis (ORCID: https://orcid.org/0000-0002-5160-1899)
- Madison Kadrmas (ORCID: https://orcid.org/0000-0002-8466-5434)
- Nico E. Conoan Nieves
- David M Garcia
- Margaret L Barry
Institutions
- University of Oregon (US)
Publication Details
- Journal
- RNA
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1261/rna.080869.125
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00