Optimization of Covalent 6-Cyanoquinazoline KRAS <sup>G12C</sup> Inhibitors for the Treatment of Solid Tumors

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Publication Details

Journal
Journal of Medicinal Chemistry
Published
2026-04-01
DOI
https://doi.org/10.1021/acs.jmedchem.5c03610
Primary Topic
Click Chemistry and Applications
Type
article
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article

Optimization of Covalent 6-Cyanoquinazoline KRAS G12C Inhibitors for the Treatment of Solid Tumors

Amanda Del Rosario, Michael P. Winters, James P. Edwards, Lawrence M. Szewczuk et al.
Journal of Medicinal Chemistry
Click Chemistry and Applications
article

Optimization of Covalent 6-Cyanoquinazoline KRAS G12C Inhibitors for the Treatment of Solid Tumors

Amanda Del Rosario, Michael P. Winters, James P. Edwards, Lawrence M. Szewczuk, Heather E. Murrey, Mark C. Richter, Tammy L. Bush, Cynthia Milligan, Jesse P. Waldo, David La, Kirk W. Shimkin, P.L. Shaffer, Michael D. Hack, Anasheh Sookezian, Sylvie Laquerre, Rasmus Hansen, Justin S. Cisar, Doree Sitkoff, Sanath K. Meegalla, Carol Yanovich, Colleen E. Keohane, Christopher B. Kelly, Matthew R. Janes, Ulf Peters, Kristi Leonard, Robert B. Kirkpatrick, Ryan Lenhart, Faraz Kazmi, Paul J. Krawczuk, Natalie Mesens, Matthew V. Lorenzi, Victoria D. Wong, Michèle Rizzolio, Yi Liu, Lian‐Sheng Li, Pingda Ren, Haleema Janjua, W. M. Jones, Christopher F. Stratton, Yvan R. F. Simonnet, Rosaura Padilla-Salinas, Wendy Eccles, Christopher G. Callas, Jenny Wen, Sheldon T. Cheung, Carlos A. Guerrero, Robert J. Rosano
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Abstract

No abstract available for this paper.
Journal of Medicinal ChemistryVol. 69(8)
Johnson & Johnson (United States) (US), Wellspring Biosciences (United States) (US)
Decent work and economic growth
Openalex Percentile: Top 35%
Click Chemistry and Applications
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