Optimization of Covalent 6-Cyanoquinazoline KRAS <sup>G12C</sup> Inhibitors for the Treatment of Solid Tumors
Authors
- Amanda Del Rosario (ORCID: https://orcid.org/0000-0001-6107-7149)
- Michael P. Winters (ORCID: https://orcid.org/0000-0003-1187-8129)
- James P. Edwards (ORCID: https://orcid.org/0000-0001-6545-1193)
- Lawrence M. Szewczuk
- Heather E. Murrey
- Mark C. Richter
- Tammy L. Bush
- Cynthia Milligan
- Jesse P. Waldo
- David La
- Kirk W. Shimkin (ORCID: https://orcid.org/0000-0003-2259-4439)
- P.L. Shaffer (ORCID: https://orcid.org/0000-0003-2249-8068)
- Michael D. Hack (ORCID: https://orcid.org/0000-0001-7136-3691)
- Anasheh Sookezian (ORCID: https://orcid.org/0000-0003-0642-4501)
- Sylvie Laquerre
- Rasmus Hansen (ORCID: https://orcid.org/0000-0001-8515-8779)
- Justin S. Cisar (ORCID: https://orcid.org/0000-0002-8693-9670)
- Doree Sitkoff (ORCID: https://orcid.org/0000-0001-7883-1961)
- Sanath K. Meegalla
- Carol Yanovich
- Colleen E. Keohane
- Christopher B. Kelly (ORCID: https://orcid.org/0000-0002-5530-8606)
- Matthew R. Janes
- Ulf Peters (ORCID: https://orcid.org/0000-0003-4664-8198)
- Kristi Leonard (ORCID: https://orcid.org/0000-0002-9398-3354)
- Robert B. Kirkpatrick (ORCID: https://orcid.org/0000-0002-8671-2361)
- Ryan Lenhart
- Faraz Kazmi (ORCID: https://orcid.org/0000-0001-7818-5488)
- Paul J. Krawczuk (ORCID: https://orcid.org/0000-0003-0413-3655)
- Natalie Mesens
- Matthew V. Lorenzi
- Victoria D. Wong
- Michèle Rizzolio
- Yi Liu (ORCID: https://orcid.org/0000-0002-6592-9262)
- Lian‐Sheng Li
- Pingda Ren (ORCID: https://orcid.org/0000-0002-4232-5271)
- Haleema Janjua
- W. M. Jones
- Christopher F. Stratton
- Yvan R. F. Simonnet
- Rosaura Padilla-Salinas
- Wendy Eccles
- Christopher G. Callas
- Jenny Wen
- Sheldon T. Cheung
- Carlos A. Guerrero
- Robert J. Rosano
Institutions
- Johnson & Johnson (United States) (US)
- Wellspring Biosciences (United States) (US)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c03610
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00