Laser-Evoked Potentials in the Early Diagnosis of Diabetic Neuropathy and Their Association with Cardiovascular Autonomic Reflex Tests: A Retrospective Observational Study in Patients with Type 2 Diabetes

: Our findings corroborated literature data regarding length-dependent LEP alterations detectable even in initial diabetic stages. The lack of correlation between LEP abnormalities and autonomic dysfunction may stem from the predominant involvement of C fibers in autonomic neuropathy, which are not adequately assessed by currently used LEPs.

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Publication Details

Journal
Brain Sciences
Published
2026-03-31
DOI
https://doi.org/10.3390/brainsci16040390
Primary Topic
Pain Management and Treatment
Type
article
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article

Laser-Evoked Potentials in the Early Diagnosis of Diabetic Neuropathy and Their Association with Cardiovascular Autonomic Reflex Tests: A Retrospective Observational Study in Patients with Type 2 Diabetes

Elisa Concon, Giacomo Zoppini, Giovanna Squintani, Marta Aventaggiato et al.
Brain Sciences
Pain Management and Treatment
article

Laser-Evoked Potentials in the Early Diagnosis of Diabetic Neuropathy and Their Association with Cardiovascular Autonomic Reflex Tests: A Retrospective Observational Study in Patients with Type 2 Diabetes

Elisa Concon, Giacomo Zoppini, Giovanna Squintani, Marta Aventaggiato, Alessia Segatti, Cristina Bittante, Enzo Bonora, V. Cacciatori, Grazia Devigili, Giovanni Umberto Borin
article en

Abstract

: Our findings corroborated literature data regarding length-dependent LEP alterations detectable even in initial diabetic stages. The lack of correlation between LEP abnormalities and autonomic dysfunction may stem from the predominant involvement of C fibers in autonomic neuropathy, which are not adequately assessed by currently used LEPs.

Brain SciencesVol. 16(4)
University of Padua (IT), Azienda Ospedaliera Universitaria Integrata Verona (IT), Ospedale di Rivoli (IT), Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
Good health and well-being
Openalex Percentile: Top 34%
Pain Management and Treatment
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Laser-Evoked Potentials in the Early Diagnosis of Diabetic Neuropathy and Their Association with Cardiovascular Autonomic Reflex Tests: A Retrospective Observational Study in Patients with Type 2 Diabetes — Elisa Concon, Giacomo Zoppini, et al. · Brain Sciences (2026) | TGRS Research Map | TGRS