Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin Resistance
implicated inflammatory and calcium signaling pathways, while Mendelian Randomization identified circulating KLK1 as a candidate causal mediator in hyperinsulinemia. Our findings refine the genetic landscape of IR, highlight adipose dysfunction as a central mechanism, and nominate new targets for mechanistic and therapeutic investigation.
Authors
- Hesam Dashti (ORCID: https://orcid.org/0000-0003-4566-0582)
- Rama Kaalia (ORCID: https://orcid.org/0000-0002-1305-0774)
- M. Wabitsch
- Melina Claussnitzer (ORCID: https://orcid.org/0000-0003-2450-736X)
- Tuomas O. Kilpeläinen (ORCID: https://orcid.org/0000-0002-8349-3028)
- Pearlyn Jia Ying Toh (ORCID: https://orcid.org/0000-0003-0907-7947)
- María J Romero-Lado (ORCID: https://orcid.org/0009-0001-9500-3292)
- Raquel Martínez
- Yaxin Jing
- Yuejiao Huang
- Mario Garcia Urena
- Cesar A. V. Cunha
- Mayank Murali
Institutions
- Broad Institute (US)
- University of Copenhagen (DK)
- University of Helsinki (FI)
- Harvard University (US)
- Universität Ulm (DE)
- Novo Nordisk Foundation (DK)
- Foundation Center (US)
- German Center for Pediatric and Adolescent Rheumatology (DE)
- Massachusetts General Hospital (US)
- Novo Nordisk (United States) (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-01
- DOI
- https://doi.org/10.64898/2026.03.31.26349822
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Novo Nordisk
- Copenhagen Graduate School for Nanoscience and Nanotechnology
- Novo Nordisk Foundation Center for Basic Metabolic Research
- National Institutes of Health