PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tumor immune escape in ovarian cancer
T cells. Our findings elucidate an immune evasion mechanism in PTEN-loss OC and suggest B7H3 blockade as a potent therapeutic strategy specifically for these tumors.
Authors
- Xinyan Ma
- Yiyu Qian (ORCID: https://orcid.org/0000-0002-3733-320X)
- Qinglei Gao (ORCID: https://orcid.org/0000-0002-9448-3423)
- Xiaodong Li (ORCID: https://orcid.org/0000-0003-2348-926X)
- Kang Yin (ORCID: https://orcid.org/0009-0006-0108-8288)
- Xulei Zheng (ORCID: https://orcid.org/0000-0002-3645-1466)
- Zheng Wang (ORCID: https://orcid.org/0000-0003-4873-505X)
- Wenwu Pan (ORCID: https://orcid.org/0000-0002-2177-7973)
- Yanqi Feng
- Shican Duan
- Lei L
- Ning Jin
- Jin-kai Jiang
- Dan Liu
- Yu Xia
Institutions
- Tongji Hospital (CN)
- China Railway Construction Machinery Research & Design Institute (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1016/j.celrep.2026.117198
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation