Impact of Enhanced Infection Control Measures on Hospital-Acquired Carbapenem-Resistant Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii

Background: infections. Given resource constraints, other CROs were excluded from the analysis. Methods: This study was conducted at a tertiary hospital in China. The baseline period (Period 1) spanned from January 1, 2022, to December 31, 2023. Starting January 1, 2024, an enhanced intervention (Period 2) was implemented, comprising weekly active surveillance for CROs, coupled with immediate notification and on-site audit with feedback to ensure prompt implementation of contact isolation for positive cases. The study compared the trends of CROs, incidence rates of hospital-acquired CROs infections, contact isolation order compliance rates, and the consumption intensity of carbapenems between the two periods. An interrupted time-series analysis was used to assess the intervention effect. Results: = 0.105). Conclusion: Enhanced infection control measures were associated with a reduction in hospital-acquired CROs infections.