Native Metabolomics Unveils Suomilide Analogs with Potent Trypsin Inhibitory Activity
). We also demonstrated that all four isolated suomilides inhibit trypsin at low nanomolar to high picomolar concentrations in a competitive bioassay, confirming the exceptional potency of this growing compound family as protease inhibitors.
Authors
- Uwe Linne (ORCID: https://orcid.org/0000-0002-1473-9063)
- Martin Baunach (ORCID: https://orcid.org/0000-0003-0822-1468)
- Tung Lam Trinh
- Stefan Kehraus
- Raphael Reher (ORCID: https://orcid.org/0000-0002-5858-1173)
- Kornelia Hardes (ORCID: https://orcid.org/0009-0000-1670-7383)
- Amira Naimi
- Christoph Ulbricht
- Teresa Marina Dreckmann
Institutions
- University of Bonn (DE)
- Philipps University of Marburg (DE)
- Fraunhofer Institute for Molecular Biology and Applied Ecology (DE)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c01380
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Philipps-Universität Marburg
- Fonds der Chemischen Industrie
- Rheinische Friedrich-Wilhelms-Universität Bonn