Damaging missense variants in innate immunity genes are associated with earlier age of breast cancer onset in <i>BRCA1</i> 185delAG carriers
BACKGROUND: PV carriers, indicating that further genetic modifiers remain to be identified. METHODS: 185delAG founder PV. RESULTS: ). CONCLUSION: penetrance and support the development of more refined, personalised risk prediction models.
Authors
- E. Friedman
- Dana Madorsky-Feldman
- Ran Elkon (ORCID: https://orcid.org/0000-0003-3440-1286)
- Sapir Shemesh
- Rinat Bernstein-Molho
- Yael Laitman
- Shelley Shoval
Institutions
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
Publication Details
- Journal
- Journal of Medical Genetics
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1136/jmg-2025-111394
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Israel Cancer Research Fund
- Tel Aviv University