Neoadjuvant mFOLFOX6 plus camrelizumab and apatinib in colon cancer and biomarker research via spatiotemporal-omics profiling
T-cells and a decreased frequency of tissue-resident memory 1 (Trm-1) and regulatory T (Treg) cells are associated with a favorable response to neoadjuvant therapy. Spatiotemporal multiomics analysis highlighted tissue-resident macrophages as potential predictive biomarkers and warrants further verification.
Authors
- Hangyu Zhang (ORCID: https://orcid.org/0000-0003-1325-3915)
- Zhou Tong (ORCID: https://orcid.org/0000-0002-9867-2838)
- W. Q. Chen
- Weidong Fang (ORCID: https://orcid.org/0000-0002-3460-2259)
- F. Liu
- Yang Zheng (ORCID: https://orcid.org/0000-0002-3775-6739)
- Linlin Liu (ORCID: https://orcid.org/0000-0002-1058-4551)
- Xiangming Xu (ORCID: https://orcid.org/0000-0002-4567-7117)
- Qi Fu
- Xiaomeng Dai
- Xuanwen Bao
- Liaoliao Gao
- Yang Gao
- Peng Zhao
- Danyang Wang
Institutions
- Zhejiang Chinese Medical University (CN)
- National Medical Products Administration (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- npj Precision Oncology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1038/s41698-026-01387-0
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- National Science and Technology Major Project