Associations between Exposure to Perfluoroalkyl Substances with Subsequent Body Composition and Glycemic Responses to Bariatric Surgery
= 0.49). No significant associations were observed for average PFHxS or PFOS. These findings suggest that PFNA and PFOS may be linked to reduced lean tissue at baseline, and that PFNA burden modestly tracks with attenuated metabolic and body composition recovery. In an ANCOVA, baseline PFNA was not significantly associated with postoperative HOMA-IR or total lean mass. Larger, longitudinal studies are needed to clarify how PFAS influence these associations.
Authors
- Damaskini Valvi (ORCID: https://orcid.org/0000-0003-4633-229X)
- Dean P. Jones (ORCID: https://orcid.org/0000-0002-2090-0677)
- Vaia Lida Chatzi
- Stephanie Marie Eick (ORCID: https://orcid.org/0000-0001-6695-3291)
- Elizabeth M. Hechenbleikner (ORCID: https://orcid.org/0000-0002-0706-7860)
- Rob McConnell (ORCID: https://orcid.org/0000-0001-5243-6410)
- Barbara Ann Gower (ORCID: https://orcid.org/0000-0001-8461-4613)
- Priyathama Vellanki (ORCID: https://orcid.org/0000-0002-6544-015X)
- Matthew Ryan Smith (ORCID: https://orcid.org/0000-0002-8889-3477)
- Tasha M Burley
- T. Ziegler
- Saketh Sankara
- Lucia A. Gonzalez Ramirez
- Paula-Dene C. Nesbeth
- Jessica A. Alvarez
- Edward Lin
Institutions
- University of Southern California (US)
- Emory University (US)
- University of Alabama at Birmingham (US)
- Atlanta VA Health Care System (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-01
- DOI
- https://doi.org/10.64898/2026.03.30.26349786
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences