Synthesis of <i>p</i> ‐Coumarates With Potential Anti‐Alzheimer's Action: Enzyme Inhibition and In Silico Studies
of 22.22 ±1.50 mM against BChE, which is notably better than galantamine's BChE inhibition. The in silico analysis suggested that compounds 14, 15, and 18 interact with AChE and BChE. Thus, p-coumaric acid derivatives represent promising prototypes for the search for new drug candidates for the treatment of AD.
Authors
- FATMA SEZER SENOL DENIZ
- Susiany Pereira Lopes (ORCID: https://orcid.org/0000-0002-7666-4917)
- Damião Pergentino de Sousa (ORCID: https://orcid.org/0000-0002-7180-4896)
- Allana Brunna Sucupira Duarte (ORCID: https://orcid.org/0000-0001-6192-3691)
- Ramin Ekhteiari Salmas (ORCID: https://orcid.org/0000-0003-3888-5070)
- Jeremias Emídio (ORCID: https://orcid.org/0009-0005-6985-8763)
- Ilkay Erdogan Orhan
Institutions
- Ministry of Industry and Trade (CZ)
- Universidade Federal da Paraíba (BR)
- King's College London (GB)
- Lokman Hekim Üniversitesi (TR)
- Gazi University (TR)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/cbdv.202503857
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Centro de Tecnologias Estratégicas do Nordeste