Schiff Base-Wrapped Co, Zn-Based Clusters with Hierarchical Chiral Structures for Therapeutic Application in Parkinson’s Disease
effectively restore dopaminergic neuron loss and improve dopamine-dependent locomotion deficits in nematodes. Additionally, these compounds inhibit α-synuclein aggregation during nematode development. These findings suggest that elaborately designed cobalt-based chiral structures have potential as novel therapeutic candidates for Parkinson's disease.
Authors
- Zhan‐Guo Jiang (ORCID: https://orcid.org/0000-0002-1500-5395)
- Cai‐Hong Zhan (ORCID: https://orcid.org/0000-0002-3612-9493)
- Ling-Cui Meng
- Jie Chen (ORCID: https://orcid.org/0000-0003-3435-0351)
- Jun Wang (ORCID: https://orcid.org/0009-0008-8475-2934)
- Zhigang Jin
- Lu-Yao Xu
Institutions
- Zhejiang Normal University (CN)
- Ministry of Education (PT)
Publication Details
- Journal
- Inorganic Chemistry
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1021/acs.inorgchem.6c00360
- Primary Topic
- Synthesis and Properties of Aromatic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang Normal University
- Natural Science Foundation of Zhejiang Province