Central Pontine Myelinolysis Leading to an Intensive Care Unit Admission

Osmotic demyelination syndrome (ODS) is a rare and serious clinical syndrome that has been associated with rapid correction of severe hyponatremia. ODS can evolve to central pontine myelinolysis (CPM), in which demyelination occurs in the pontine region, and less commonly extrapontine myelinolysis (EPM), involving other brain regions. We present the case of a 52-year-old alcoholic man admitted for community-acquired pneumonia who developed CPM following rapid correction of severe hyponatremia. This case highlights the importance of careful correction of sodium levels, particularly in high-risk patients.

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Journal
Cureus
Published
2026-03-31
DOI
https://doi.org/10.7759/cureus.106210
Primary Topic
Electrolyte and hormonal disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Central Pontine Myelinolysis Leading to an Intensive Care Unit Admission

Eugeniu Gisca, Odete Gomes, Ana Alburquerque, Miguel Santos et al.
Cureus
Electrolyte and hormonal disorders
article

Central Pontine Myelinolysis Leading to an Intensive Care Unit Admission

Eugeniu Gisca, Odete Gomes, Ana Alburquerque, Miguel Santos, Fernando Henriques, Ana Cunha
article en

Abstract

Osmotic demyelination syndrome (ODS) is a rare and serious clinical syndrome that has been associated with rapid correction of severe hyponatremia. ODS can evolve to central pontine myelinolysis (CPM), in which demyelination occurs in the pontine region, and less commonly extrapontine myelinolysis (EPM), involving other brain regions. We present the case of a 52-year-old alcoholic man admitted for community-acquired pneumonia who developed CPM following rapid correction of severe hyponatremia. This case highlights the importance of careful correction of sodium levels, particularly in high-risk patients.

CureusVol. 18(3)
Instituto Politécnico de Leiria (PT)
Good health and well-being
Openalex Percentile: Top 36%
Electrolyte and hormonal disorders
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