Hypoxia and DNA-Repair Radiosensitivity Signatures Are Associated with Radiotherapy-Modified Survival in TCGA Breast Cancer, with External Prognostic Validation of the Hypoxia Score in METABRIC
= 0.0042). Overall, these results suggest that hypoxia and DSB-repair capacity capture two complementary sides of radiosensitivity and RT-modified survival patterns, and they support further prospective testing and validation in independent datasets with strong RT annotation.
Authors
- Mei‐Han Chen
- Timothy Smith (ORCID: https://orcid.org/0000-0002-3945-630X)
- Jimmy Carter Osei (ORCID: https://orcid.org/0000-0003-2963-4114)
Institutions
- Bangor University (GB)
Publication Details
- Journal
- BioTech
- Published
- 2026-03-31
- DOI
- https://doi.org/10.3390/biotech15020028
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00