Remote γ-C(sp <sup>3</sup> )–H Activation of Masked Aliphatic Alcohols Enables Pyridone Ether Synthesis
-fluorobenzenesulfonimide (NFSI) as a key oxidant is crucial for over-riding the conventional β-selectivity, thereby affording γ-functionalized products. This transformation exhibits a broad substrate scope and a high functional group tolerance. Overall, this strategy provides an efficient and practical approach to pyridone ether synthesis via remote C-H activation.
Authors
- Y. Hu (ORCID: https://orcid.org/0000-0002-0078-8497)
- Chao Jiang (ORCID: https://orcid.org/0000-0002-9228-1924)
- Qing He (ORCID: https://orcid.org/0000-0002-4172-1547)
- Yingfeng Tu (ORCID: https://orcid.org/0000-0002-8848-127X)
- Xing Liu
Institutions
- Nanjing University of Science and Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1021/acs.joc.6c00241
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China