The prostatic acid phosphatase in prostate cancer: A novel theranostic target

Ga]Ga-OncoACP3-DOTA PET. Early clinical data demonstrate competitive diagnostic performance compared with PSMA-PET, markedly reduced salivary/lacrimal gland and renal uptake, and advantageous pharmacokinetics characterized by increasing tumor uptake and improving tumor-to-background ratios over time. Preclinical and translational evidence further supports the feasibility of ACP3-targeted radioligand therapy. This review summarizes the biological features of ACP3, its historical and current role as a biomarker, and emerging therapeutic applications, with a primary focus on ACP3-targeted molecular imaging and radioligand therapy. The available evidence positions ACP3 as a compelling next-generation theranostic target with the potential to overcome key limitations of PSMA-based approaches and expand precision treatment options for patients with prostate cancer.