The RAGE–Ferroptosis Axis Drives Oxidative Stress-Associated Inflammatory Lung Injury in Viral Infection
. Moreover, RAGE inhibition decreased M1 macrophage and neutrophil infiltration and reduced pro-inflammatory cytokines. Collectively, these findings reveal that RAGE activation drives ferroptosis and amplifies oxidative stress-associated lung injury, whereas RAGE inhibition mitigates tissue damage via the ACSL4/POR/GPX4 pathway and immunomodulation. This study identifies the RAGE-ferroptosis axis as a potential therapeutic target for severe pulmonary inflammation.
Authors
- Junhao Luo (ORCID: https://orcid.org/0000-0003-0137-4365)
- Siyu Pu
- Rongbao Gao (ORCID: https://orcid.org/0000-0003-1139-3607)
- Peiqing He
- Haijun Zhu
- Simin Cui
Institutions
- Anhui Medical University (CN)
- National Institute for Viral Disease Control and Prevention (CN)
Publication Details
- Journal
- Antioxidants
- Published
- 2026-03-31
- DOI
- https://doi.org/10.3390/antiox15040434
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Center for Disease Control and Prevention
- Centers for Disease Control and Prevention
- National Key Research and Development Program of China