Base-resolution DNA methylome of human MDS hematopoietic stem cell reveals TET2-GFI1 epigenetic axis repressing MDS
, contributing to the expansion of the MDS or aged hematopoietic stem and progenitor cell pool. Our study not only charts the base-resolution DNA methylome of human MDS HSCs but also reveals a TET2-GFI1 axis that safeguards HSC homeostasis. These findings provide mechanistic insight into how aberrant DNA methylation drives HSC dysfunction in MDS and offer an epigenomic resource for discovering regulators and therapeutic targets at the stem cell level. Supplementary Information: The online version contains supplementary material available at 10.1007/s44466-026-00034-4.
Authors
- Qicong Shen
- Jian Lu (ORCID: https://orcid.org/0000-0002-0267-9243)
- Yuhang Li (ORCID: https://orcid.org/0000-0003-3530-8331)
- Yanmei Han
- Liangding Hu
- Bin Zhang
- Xuetao Cao
- Yan Gu
- Na Liu
- Qian Zhang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- Shanghai University of Traditional Chinese Medicine (CN)
- People's Liberation Army No. 150 Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Chinese People’s Liberation Army 263 hospital (CN)
Publication Details
- Journal
- Immunity & Inflammation
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1007/s44466-026-00034-4
- Primary Topic
- Blood disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences