The performance of the WHO mutation catalog of <i>Mycobacterium tuberculosis</i> in the diagnosis of drug resistance to rifampicin-resistant strains in Wenzhou, China

complex (MTBC) and their association with drug resistance published by the WHO in 2021 and 2023, this study evaluated the predictive performance of the catalogs for resistance to nine anti-tuberculosis drugs among 214 MTBC isolates from Wenzhou Central Hospital. The results demonstrated high accuracy of resistance prediction using the second edition. Three potential resistance-associated mutations were also identified. These findings not only confirm the reliability of the current catalog but may also provide valuable insights for future updates.