Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER+ HER2− locally-advanced or metastatic breast cancer
BC cell lines exhibit profound shifts in chromatin accessibility, with the transcription factors, FOXA1 and FOXM1, implicated in gene expression of NR-upregulated proliferative pathways.
Authors
- Vasumathi Kameswaran (ORCID: https://orcid.org/0000-0003-2552-6183)
- Mary Gates (ORCID: https://orcid.org/0009-0006-8576-2769)
- Ciara Metcalfe (ORCID: https://orcid.org/0000-0001-7233-661X)
- Jennifer M. Giltnane (ORCID: https://orcid.org/0000-0002-8333-9995)
- Bence Dániel (ORCID: https://orcid.org/0000-0002-2410-8767)
- Heather M. Moore (ORCID: https://orcid.org/0000-0002-7098-3888)
- Pablo Perez-Moreno (ORCID: https://orcid.org/0009-0006-7083-2867)
- Jane Guan
- Kareem A. Heslop (ORCID: https://orcid.org/0000-0002-2618-2530)
- Jackson Liang (ORCID: https://orcid.org/0000-0003-3778-4614)
- Yuxin Liang (ORCID: https://orcid.org/0000-0002-1143-423X)
- Christy C. Ong (ORCID: https://orcid.org/0009-0007-0139-6392)
- Ching-Wei Chang
- Minyi Shi (ORCID: https://orcid.org/0000-0003-1616-8353)
- Jennifer Eng-Wong
- N. C. Turner
- Junko Aimi
- Komal L. Jhaveri
- Elgene Lim
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Garvan Institute of Medical Research (AU)
- Institute of Cancer Research (GB)
- Cornell University (US)
- Gene Therapy Laboratory (FR)
- Royal Marsden Hospital (GB)
- Genomic Health (United States) (US)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1038/s41467-026-71233-1
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Genentech