Manganese-Templated Nontrivial Structures for MRI and Therapy

release, ROS accumulation, and caspase-dependent apoptosis. In vivo, Mn-TK and Mn-BR achieve tumor-specific accumulation, strong MRI contrast, and pronounced growth inhibition in subcutaneous glioblastoma models, while Mn-[2]C shows minimal selectivity and higher systemic toxicity. Importantly, in a spontaneous orthotopic glioblastoma model, both Mn-TK and Mn-BR provided robust BBB permeability and persistent, tumor-specific MRI enhancement, confirming their potential for precise MRI-guided tumor visualization. This research marks a major leap forward in medical nanotechnology, unveiling a new class of metal-organic structures that seamlessly integrates imaging and therapy. By unlocking their full potential, these structures promise to revolutionize MRI diagnostics, precision medicine, and next-generation cancer treatments, paving the way for unparalleled clinical outcomes.

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Publication Details

Journal
Journal of the American Chemical Society
Published
2026-04-01
DOI
https://doi.org/10.1021/jacs.5c19016
Primary Topic
Metal-Organic Frameworks: Synthesis and Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Manganese-Templated Nontrivial Structures for MRI and Therapy

Rick Heinz, Maylis Boitet, Matteo Lusi, Thirumurugan Prakasam et al.
Journal of the American Chemical Society
Metal-Organic Frameworks: Synthesis and Applications
article

Manganese-Templated Nontrivial Structures for MRI and Therapy

Rick Heinz, Maylis Boitet, Matteo Lusi, Thirumurugan Prakasam, Ali Trabolsi, Sneha Thomas, Farah Benyettou, Osama Abdullah, Sheri L. Holmen, Mostafa Khair, Edward W. Hsu, Diana Yu, Rainer Straubinger, J. Del Monte, Haidee Paterson, Maryam Alkaabi, Nosayba Al Damook, Mamoun Abelbaki, Carlos Platas-Iglesias
article en

Abstract

release, ROS accumulation, and caspase-dependent apoptosis. In vivo, Mn-TK and Mn-BR achieve tumor-specific accumulation, strong MRI contrast, and pronounced growth inhibition in subcutaneous glioblastoma models, while Mn-[2]C shows minimal selectivity and higher systemic toxicity. Importantly, in a spontaneous orthotopic glioblastoma model, both Mn-TK and Mn-BR provided robust BBB permeability and persistent, tumor-specific MRI enhancement, confirming their potential for precise MRI-guided tumor visualization. This research marks a major leap forward in medical nanotechnology, unveiling a new class of metal-organic structures that seamlessly integrates imaging and therapy. By unlocking their full potential, these structures promise to revolutionize MRI diagnostics, precision medicine, and next-generation cancer treatments, paving the way for unparalleled clinical outcomes.

Journal of the American Chemical SocietyVol. 148(15)
Universidade da Coruña (ES), University of Bern (CH), University of Utah (US), University of Limerick (IE), Huntsman Cancer Institute (US), United States Arctic Research Commission (US), Division of Chemistry (US), Rede de Química e Tecnologia (PT), New York University (US)
New York University Abu Dhabi, Ministerio de Ciencia, Innovación y Universidades, York University, Agencia Estatal de Investigación, ASPIRE
Openalex Percentile: Top 39%
Metal-Organic Frameworks: Synthesis and Applications
DOIOpen Access PDFOpenAlex
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