Therapeutic Drug Monitoring in Tuberculosis: What a Pulmonologist Must Know?

Case sCenarioA 17-year-old immunocompetent female presented with prolonged pyrexia of unknown origin and constitutional symptoms, including fatigue and night sweats, for 1 year.She was initiated on first-line ATT based on clinical features, radiological evidence of mediastinal lymphadenopathy, and cytopathology demonstrating necrotizing granulomatous inflammation on endobronchial ultrasound-guided transbronchial needle aspiration.After 8 months of ATT, she continued to have a persistent fever.Repeat imaging revealed unresolved mediastinal lymphadenopathy.Review of her treatment history confirmed optimal weight-based dosing and adherence to