Hyperhomocysteinemia as a risk factor for cerebral venous thrombosis: a systematic review and meta-analysis of the case–control studies

Introduction: Cerebral venous thrombosis (CVT) is relatively rare but has severe thrombotic manifestations with a high mortality rate, the potential to cause disability, and the propensity to recur. There are limited data on the role of hyperhomocysteinemia as a risk factor for CVT. In this context, no large-scale meta-analysis has been conducted. Our meta-analysis aims to assess hyperhomocysteinemia as a risk factor for CVT using the data from case-control studies. Methods: statistic. For each exposure-outcome pair, a random or fixed effect meta-analysis was conducted based on the degree of heterogeneity to pool the odds ratio (OR), prevalence of hyperhomocysteinemia, and the mean difference (MD) in homocysteine level with a 95% confidence interval (CI) from the individual studies using RevMan version 5.4. Results: = 90.4%). Conclusions: In conclusion, this meta-analysis demonstrates a strong association between CVT and hyperhomocysteinemia, with a notably high prevalence among CVT patients. While these findings suggest that hyperhomocysteinemia may be a potential risk factor for CVT, current evidence is limited. Larger-scale studies are needed to further clarify this association and inform future clinical recommendations.