A Small-Molecule Platform Demonstrates Light-Activated Synergy Between Cuproptosis and Photodynamic Tumor Therapy
), reducing GSH copper-binding capacity, thereby liberating copper ions and selectively inducing cuproptosis. In murine tumor models, NC demonstrated high biosafety and superior tumor suppression to PDT alone, achieving complete inhibition over 14 d. Thus, NC establishes PDT as a controllable cuproptosis inducer, converting GSH from inhibitor to trigger and expanding the therapeutic potential of both modalities.
Authors
- Daipeng Huang
- Jiangli Fan
- Jianjun Du
- Jikai Yin
- Yi Hu (ORCID: https://orcid.org/0000-0003-3317-4771)
- Saran Long (ORCID: https://orcid.org/0009-0005-3860-6854)
- Danhong Zhou
- Xiaojun Peng
- Yuxin Yang
- Haolan Li
Institutions
- Dalian University of Technology (CN)
- Dalian University (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00424
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities