Modeling an SPR Sensor for Carcinoma-Related Refractive-Index Detection: The Case of CaF2/Au/Si3N4/BP Multilayer System

in the same regime. Composite indicators (figure of merit and contrast signal factor) peak at intermediate levels, whereas resonance broadening at higher levels reduces the quality factor and increases the inferred limit of detection, evidencing a sensitivity-resolution trade-off. Benchmarking against reported SPR platforms indicates that BP-assisted interface engineering provides a competitive low-level operating window within a preliminary refractive-index-sensing framework that is relevant to future biosensor design. These results motivate further experimental validation, including BP stabilization, surface biofunctionalization, and practical implementation under liquid-phase sensing conditions.

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Publication Details

Journal
Biosensors
Published
2026-04-01
DOI
https://doi.org/10.3390/bios16040198
Primary Topic
Plasmonic and Surface Plasmon Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Modeling an SPR Sensor for Carcinoma-Related Refractive-Index Detection: The Case of CaF2/Au/Si3N4/BP Multilayer System

Cristian Vacacela Gómez, Talía Tene, Martha Ximena Dávalos Villegas
Biosensors
Plasmonic and Surface Plasmon Research
article

Modeling an SPR Sensor for Carcinoma-Related Refractive-Index Detection: The Case of CaF2/Au/Si3N4/BP Multilayer System

Cristian Vacacela Gómez, Talía Tene, Martha Ximena Dávalos Villegas
article en

Abstract

in the same regime. Composite indicators (figure of merit and contrast signal factor) peak at intermediate levels, whereas resonance broadening at higher levels reduces the quality factor and increases the inferred limit of detection, evidencing a sensitivity-resolution trade-off. Benchmarking against reported SPR platforms indicates that BP-assisted interface engineering provides a competitive low-level operating window within a preliminary refractive-index-sensing framework that is relevant to future biosensor design. These results motivate further experimental validation, including BP stabilization, surface biofunctionalization, and practical implementation under liquid-phase sensing conditions.

BiosensorsVol. 16(4)
Universidad Técnica Particular de Loja (EC), Escuela Superior Politécnica del Chimborazo (EC), Universidad Ecotec (EC), University of Calabria (IT)
Universidad Técnica Particular de Loja
Openalex Percentile: Top 37%
Plasmonic and Surface Plasmon Research
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Modeling an SPR Sensor for Carcinoma-Related Refractive-Index Detection: The Case of CaF2/Au/Si3N4/BP Multilayer System — Cristian Vacacela Gómez, Talía Tene, et al. · Biosensors (2026) | TGRS Research Map | TGRS