The TGF-βR1 inhibitor galunisertib re-shapes the PDAC-TME by limiting decidual-like natural killer cells polarization
NKs as a novel cell subset expanded in PDAC and underscores the role of TGF-β1/TGF-βR1 signalling in promoting a pro-tumoral NKs GAL-treatment emerges as immunomodulator able in re-educating pro-tumor NKs cells in PDAC.
Authors
- Silvia Uccella (ORCID: https://orcid.org/0000-0002-5714-7295)
- Matteo Gallazzi (ORCID: https://orcid.org/0000-0001-6662-9352)
- G. Nappo
- A. Pessi
- Pier Francesco Ferrucci (ORCID: https://orcid.org/0000-0001-6255-5851)
- Annalisa Grimaldi
- Daniele Mercatelli (ORCID: https://orcid.org/0000-0003-3228-0580)
- Patrizia Borsotti (ORCID: https://orcid.org/0000-0002-9789-528X)
- Andrea Resovi (ORCID: https://orcid.org/0000-0001-9560-0815)
- Paola C. Muti (ORCID: https://orcid.org/0000-0003-0339-8520)
- Marta Tagliabue (ORCID: https://orcid.org/0000-0002-7879-4846)
- Dorina Belotti (ORCID: https://orcid.org/0000-0002-3868-9144)
- Riccardo Ricotta (ORCID: https://orcid.org/0000-0002-4568-5184)
- Nicoló Baranzini (ORCID: https://orcid.org/0000-0001-6996-4797)
- Lorenzo Mortara (ORCID: https://orcid.org/0000-0002-4757-7101)
- Maria Teresa Palano
- Martina Cucchiara (ORCID: https://orcid.org/0000-0003-0030-5149)
- Maria Gemelli (ORCID: https://orcid.org/0000-0003-1143-0252)
- Francesco Acquati (ORCID: https://orcid.org/0000-0002-9537-400X)
- Giulia Garattini
- Barbara Bassani (ORCID: https://orcid.org/0000-0002-8002-1607)
- Gianpiero Catalano
- Federica Di Leva
- Cristian Rubuano
- Antonino Bruno
- Alessandro Zerbi
Institutions
- University of Insubria (IT)
- Humanitas University (IT)
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- MultiMedica (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Cell Death and Disease
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1038/s41419-026-08581-9
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondazione Cariplo
- Associazione Italiana per la Ricerca sul Cancro
- Università degli Studi dell'Insubria