The TGF-βR1 inhibitor galunisertib re-shapes the PDAC-TME by limiting decidual-like natural killer cells polarization

NKs as a novel cell subset expanded in PDAC and underscores the role of TGF-β1/TGF-βR1 signalling in promoting a pro-tumoral NKs GAL-treatment emerges as immunomodulator able in re-educating pro-tumor NKs cells in PDAC.

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Publication Details

Journal
Cell Death and Disease
Published
2026-03-31
DOI
https://doi.org/10.1038/s41419-026-08581-9
Primary Topic
Immune Cell Function and Interaction
Type
article
Field-Weighted Citation Impact
0.00

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article

The TGF-βR1 inhibitor galunisertib re-shapes the PDAC-TME by limiting decidual-like natural killer cells polarization

Silvia Uccella, Matteo Gallazzi, G. Nappo, A. Pessi et al.
Cell Death and Disease
Immune Cell Function and Interaction
article

The TGF-βR1 inhibitor galunisertib re-shapes the PDAC-TME by limiting decidual-like natural killer cells polarization

Silvia Uccella, Matteo Gallazzi, G. Nappo, A. Pessi, Pier Francesco Ferrucci, Annalisa Grimaldi, Daniele Mercatelli, Patrizia Borsotti, Andrea Resovi, Paola C. Muti, Marta Tagliabue, Dorina Belotti, Riccardo Ricotta, Nicoló Baranzini, Lorenzo Mortara, Maria Teresa Palano, Martina Cucchiara, Maria Gemelli, Francesco Acquati, Giulia Garattini, Barbara Bassani, Gianpiero Catalano, Federica Di Leva, Cristian Rubuano, Antonino Bruno, Alessandro Zerbi
article en

Abstract

NKs as a novel cell subset expanded in PDAC and underscores the role of TGF-β1/TGF-βR1 signalling in promoting a pro-tumoral NKs GAL-treatment emerges as immunomodulator able in re-educating pro-tumor NKs cells in PDAC.

Cell Death and Disease
University of Insubria (IT), Humanitas University (IT), University of Milan (IT), Mario Negri Institute for Pharmacological Research (IT), MultiMedica (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), IRCCS Humanitas Research Hospital (IT), University of Bologna (IT)
Fondazione Cariplo, Associazione Italiana per la Ricerca sul Cancro, Università degli Studi dell'Insubria
Good health and well-being
Openalex Percentile: Top 33%
Immune Cell Function and Interaction
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