Farnesoid X receptor-dependent microbiome-bile acid signaling mediates obstructive sleep apnea-induced atherosclerosis
mice. Knockout of FXR disrupted microbiome shift under IHC and uncoupled microbial bile acid metabolism from vascular lesion development, thereby protecting against aortic atherosclerosis. These findings show that FXR has a central role in linking IHC, microbial bile acid metabolism, and cardiovascular pathology.
Authors
- GG Haddad
- Celeste Allaband (ORCID: https://orcid.org/0000-0003-1832-4858)
- Orit Poulsen
- Jason D. Meadows
- Amanda Birmingham (ORCID: https://orcid.org/0000-0002-4117-3317)
- Simone Zuffa (ORCID: https://orcid.org/0000-0001-7237-3402)
- Jennifer Cao (ORCID: https://orcid.org/0000-0001-6129-9542)
- Ipsita Mohanty
- Rob Knight
- Daniel McDonald
- Gail Ackermann
- Jin Xue
- Madison Ambre
- Pieter C. Dorrestein
Institutions
- University of San Diego (US)
- University of California San Diego (US)
- La Jolla Bioengineering Institute (US)
- Institute for Advanced Study (DE)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-01
- DOI
- https://doi.org/10.64898/2026.03.31.715631
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00