Mapping immunosuppressive terrain in high-grade serous ovarian cancer: tumor-intrinsic, stromal, and spatial drivers of therapy response
High-grade serous ovarian cancer (HGSOC) features a profoundly immunosuppressive tumor microenvironment (TME) that limits immunotherapy. Yet resistance is multilayered and spatially heterogeneous without an integrated framework. This review synthesizes recent advances that map multifaceted immune resistance in HGSOC across tumor-intrinsic, stromal, and spatial dimensions. Furthermore, we discuss potential translational strategies of remodeling the TME, with the goal of offering a context-aware roadmap for rational combination immunotherapy.
Authors
- S. N. Liu
- Xianghua Huang (ORCID: https://orcid.org/0000-0002-0104-4318)
- Yanfang Du (ORCID: https://orcid.org/0000-0001-6918-1514)
- Yanpeng Tian (ORCID: https://orcid.org/0000-0001-8049-1281)
- Shouze Liu (ORCID: https://orcid.org/0000-0003-0932-0409)
- Zhongkang Li (ORCID: https://orcid.org/0000-0001-6654-4674)
- Wenhua Liu (ORCID: https://orcid.org/0000-0002-0267-3423)
- Bilan Li
- Rulan Jiang
Institutions
- Hebei Medical University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Changsha Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Cangzhou Central Hospital (CN)
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- npj Precision Oncology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1038/s41698-026-01392-3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hebei Province