Metastasis as a Multiorgan Disease: Toward Organ-Informed Precision Oncology
Metastasis is a multiorgan disease in which disseminated cancer cells undergo profound, tissue-specific reprogramming that reshapes their identity, vulnerabilities, and therapeutic responses. We argue for an organ-informed precision oncology framework that integrates these site-imposed programs into treatment design.
Authors
- Chirayu Mohindroo (ORCID: https://orcid.org/0000-0002-5825-3356)
- A. Thomas
- Joan Massagué (ORCID: https://orcid.org/0000-0001-9324-8408)
- Julien Sage (ORCID: https://orcid.org/0000-0002-8928-9968)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Stanford Medicine (US)
- National Cancer Institute (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-2052
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00