A meta-analysis supporting the role of positive airway pressure therapy in lowering pulmonary artery pressure in obstructive sleep apnoea and obesity hypoventilation syndrome with severe obstructive sleep apnoea

<title>Extract</title> Obstructed breathing during sleep, whether present as an isolated disorder (obstructive sleep apnoea (OSA)) or accompanied by hypoventilation in the obese (obesity hypoventilation syndrome (OHS)/OSA), is associated with significant cardiovascular morbidity and mortality. Pulmonary hypertension (PH) is prevalent in both disorders and is present in approximately 30% of patients with OSA [1–3], and in more than 50% in those with OHS [4]. However, the prevalence of PH has yet to be determined using right heart catheterisation after rigorously excluding concomitant cardiovascular and respiratory diseases that could affect haemodynamics.