Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from the genetically modified Trichoderma reesei strain DP‐Nzh109

strain DP-Nzh109 by Genencor International B.V. The genetic modifications do not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism and its DNA. It is intended to be used in two food manufacturing processes. Since residual amounts of food enzyme-total organic solids are removed in these two processes, dietary exposure was not estimated and toxicity testing was considered unnecessary. A search for the homology of the amino acid sequence of the glucan 1,4-α-glucosidase to known allergens was made and a match with one respiratory allergen was found. The Panel considered that a risk of allergic reactions upon dietary exposure cannot be excluded, but that the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.

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Publication Details

Journal
EFSA Journal
Published
2026-04-01
DOI
https://doi.org/10.2903/j.efsa.2026.10017
Primary Topic
Occupational exposure and asthma
Type
article
Field-Weighted Citation Impact
0.00

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article

Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from the genetically modified Trichoderma reesei strain DP‐Nzh109

Francesco Catania, José Manuel Barat Baviera, Laurence Vernis, Daniele Cavanna et al.
EFSA Journal
Occupational exposure and asthma
article

Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from the genetically modified Trichoderma reesei strain DP‐Nzh109

Francesco Catania, José Manuel Barat Baviera, Laurence Vernis, Daniele Cavanna, Cristina Fernandez, Baltasar Mayo, Holger Zorn, Henk Van Loveren, Claudia Bolognesi, Ralf Greiner, Alicja Mortensen, Yrjö Henrik Roos, Gabriele Gadermaier, Yi Xuan Liu, Marize L. M. Solano, Simone Lunardi, EFSA Panel on Food Enzymes (FEZ)
article en

Abstract

strain DP-Nzh109 by Genencor International B.V. The genetic modifications do not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism and its DNA. It is intended to be used in two food manufacturing processes. Since residual amounts of food enzyme-total organic solids are removed in these two processes, dietary exposure was not estimated and toxicity testing was considered unnecessary. A search for the homology of the amino acid sequence of the glucan 1,4-α-glucosidase to known allergens was made and a match with one respiratory allergen was found. The Panel considered that a risk of allergic reactions upon dietary exposure cannot be excluded, but that the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.

EFSA JournalVol. 24(4)
European Food Safety Authority
Openalex Percentile: Top 33%
Occupational exposure and asthma
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