Pyrazole-Thiazole Hybrids: Synthesis and Biological Evaluation against <i>Trypanosoma cruzi</i> and <i> <i>Mycobacterium tuberculosis</i> </i>

analyses suggested preferential stabilization of halogenated derivatives through hydrophobic and π-driven interactions in structurally related enzymatic pockets, used here as an exploratory model. Taken together, these findings demonstrate that halogen substitution strongly modulates affinity and biological performance, supporting pyrazole-thiazole hybrids as promising scaffolds for further optimization against neglected-parasite pathogens. Future studies expanding halogen patterns and probing alternative binding pockets may improve potency and target selectivity across this chemical space.

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Publication Details

Journal
ACS Omega
Published
2026-04-01
DOI
https://doi.org/10.1021/acsomega.5c12469
Primary Topic
Trypanosoma species research and implications
Type
article
Field-Weighted Citation Impact
0.00

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article

Pyrazole-Thiazole Hybrids: Synthesis and Biological Evaluation against Trypanosoma cruzi and Mycobacterium tuberculosis

Cynthia Nathália Pereira, Maurício Silva dos Santos, Mirian Cláudia de Souza Pereira, Lorraine Martins Rocha Orlando et al.
ACS Omega
Trypanosoma species research and implications
article

Pyrazole-Thiazole Hybrids: Synthesis and Biological Evaluation against Trypanosoma cruzi and Mycobacterium tuberculosis

Cynthia Nathália Pereira, Maurício Silva dos Santos, Mirian Cláudia de Souza Pereira, Lorraine Martins Rocha Orlando, Oswaldo Julio Ramirez Delgado, Christian S Canales Carnero, Cesar Augusto Roque-Borda, Edinaldo Castro de Oliveira, Fernando Rogério Pavan
article en

Abstract

analyses suggested preferential stabilization of halogenated derivatives through hydrophobic and π-driven interactions in structurally related enzymatic pockets, used here as an exploratory model. Taken together, these findings demonstrate that halogen substitution strongly modulates affinity and biological performance, supporting pyrazole-thiazole hybrids as promising scaffolds for further optimization against neglected-parasite pathogens. Future studies expanding halogen patterns and probing alternative binding pockets may improve potency and target selectivity across this chemical space.

ACS OmegaVol. 11(14)
Zimmer Biomet (United States) (US), Catholic University of Santa María (PE), Fundação Oswaldo Cruz (BR), Universidade Federal de Itajubá (BR), Universidade Estadual Paulista (Unesp) (BR)
Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Fundação Oswaldo Cruz, Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica
Openalex Percentile: Top 36%
Trypanosoma species research and implications
DOIOpen Access PDFOpenAlex
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Pyrazole-Thiazole Hybrids: Synthesis and Biological Evaluation against <i>Trypanosoma cruzi</i> and <i> <i>Mycobacterium tuberculosis</i> </i> — Cynthia Nathália Pereira, Maurício Silva dos Santos, et al. · ACS Omega (2026) | TGRS Research Map | TGRS