Spiropenicitrinol A: A Spirocyclic Polyketide from <i>Penicillium citrinum</i> with Potent Anti-inflammatory Activity
showed potent anti-inflammatory activity by inhibiting LPS-induced NO, TNF-α, IL-6, and IL-1β production in RAW264.7 cells. These findings indicated that this complex spirocyclic architecture could serve as a promising scaffold for the further development of novel anti-inflammatory agents.
Authors
- Qing Rong Qi
- Haitian Zhang (ORCID: https://orcid.org/0000-0002-1122-8647)
- Yujiao Shu
- Zengjun Guo (ORCID: https://orcid.org/0000-0003-3266-6280)
- Guanqun Zhan (ORCID: https://orcid.org/0000-0002-0848-0147)
- Tao Yang
- Nan Wang
- Zhetong Liu
- Xiaozhi Huang
Institutions
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1021/acs.orglett.6c00687
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shaanxi Administration of Traditional Chinese Medicine
- National Natural Science Foundation of China