High Drug Encapsulation Capacity in Cyclodextrin-Based Nanoparticles: Characterization and <i>In Vivo</i> Antitumor Efficacy in Tumor-Bearing Mice

Insufficient drug encapsulation, typically at about 10 wt %, remains a major challenge in the design of nanotechnology-based drug delivery systems. In this study, we created cyclodextrin-based nanoparticles (CDNP_PEGs), synthesized by the hyperbranched polymerization of cyclodextrins using a diepoxy poly-(ethylene glycol) linker, which exhibited a high drug encapsulation capacity of up to 54 wt % using the xanthone derivative α-mangostin (MGS) as a model compound. Evaluation in a tumor-bearing mouse model indicated that a single intravenous administration via the tail vein induced a significantly greater antitumor effect compared with free MGS. These results demonstrate the potential of CDNP_PEGs as promising high-capacity carriers for the delivery of anticancer drugs.

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Publication Details

Journal
ACS Bio & Med Chem Au
Published
2026-04-01
DOI
https://doi.org/10.1021/acsbiomedchemau.5c00220
Primary Topic
Natural Compound Pharmacology Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

High Drug Encapsulation Capacity in Cyclodextrin-Based Nanoparticles: Characterization and In Vivo Antitumor Efficacy in Tumor-Bearing Mice

Liliana de Campo, Mina Sakuragi, Tomoki Nishimura, Tomoki Kosugi et al.
ACS Bio & Med Chem Au
Natural Compound Pharmacology Studies
article

High Drug Encapsulation Capacity in Cyclodextrin-Based Nanoparticles: Characterization and In Vivo Antitumor Efficacy in Tumor-Bearing Mice

Liliana de Campo, Mina Sakuragi, Tomoki Nishimura, Tomoki Kosugi, Noriko Miyamoto, Riku Kawasaki, T. Saito, Reina Kobayashi, Madoka Toya, Kazuo Sakurai
article en

Abstract

Insufficient drug encapsulation, typically at about 10 wt %, remains a major challenge in the design of nanotechnology-based drug delivery systems. In this study, we created cyclodextrin-based nanoparticles (CDNP_PEGs), synthesized by the hyperbranched polymerization of cyclodextrins using a diepoxy poly-(ethylene glycol) linker, which exhibited a high drug encapsulation capacity of up to 54 wt % using the xanthone derivative α-mangostin (MGS) as a model compound. Evaluation in a tumor-bearing mouse model indicated that a single intravenous administration via the tail vein induced a significantly greater antitumor effect compared with free MGS. These results demonstrate the potential of CDNP_PEGs as promising high-capacity carriers for the delivery of anticancer drugs.

ACS Bio & Med Chem AuVol. 6(2)
Hiroshima University (JP), Australian Nuclear Science and Technology Organisation (AU), Shinshu University (JP), The University of Kitakyushu (JP), Sojo University (JP), Aichi Institute of Technology (JP)
Sumitomo Foundation, Canon Foundation for Scientific Research, Japan Science and Technology Corporation, Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science
Good health and well-being
Openalex Percentile: Top 36%
Natural Compound Pharmacology Studies
DOIOpen Access PDFOpenAlex
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High Drug Encapsulation Capacity in Cyclodextrin-Based Nanoparticles: Characterization and <i>In Vivo</i> Antitumor Efficacy in Tumor-Bearing Mice — Liliana de Campo, Mina Sakuragi, et al. · ACS Bio & Med Chem Au (2026) | TGRS Research Map | TGRS