Distinct dendritic cell cytoskeletal programs dictate synapse architecture and CD8+ T cell fate
dendritic cells generate memory T cells with a Tc17-like functional profile and robust recall capacity. Our work reveals that DC synapse architecture is a key determinant of T cell fate, linking the physical organization of the cell to distinct immunological outcomes.
Authors
- Jérémie Rossy (ORCID: https://orcid.org/0000-0002-5128-5283)
- Camille D Clamagirand
- Christoph Ratswohl (ORCID: https://orcid.org/0000-0001-5413-0730)
- Daniel F. Legler (ORCID: https://orcid.org/0000-0001-8610-4764)
- Marc W. Schmid (ORCID: https://orcid.org/0000-0001-9554-5318)
- Nadine Anslinger
- Theresia Eich
Institutions
- University of Bern (CH)
- University of Konstanz (DE)
- Schmid (Germany) (DE)
- Biotechnology Institute Thurgau (CH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3389/fimmu.2026.1716644
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Bern