Transcriptomic Landscape and Regulatory Pathways of Drought Response in Rice (Oryza sativa L.): A Meta-Analysis of Microarray and RNA-Seq Data

underwater deficit. Tissue-specific regulatory pathways were identified using STRING, g:Profiler, and PANTHER. Our analysis resolved distinct functional divergence, where shoots prioritize photosynthetic adjustment while roots emphasize transcriptional and chromatin reprogramming. Beyond validating core ABA signaling, we uncover a novel metabolic pivot: the activation of glyoxylate and dicarboxylate metabolism to mitigate drought-induced carbon starvation. We further identify specialized transport systems for ions and electrons across organelle membranes, alongside cellular reorganization driven by autophagy and actin-dependent cytoskeleton remodeling. These findings highlight a sophisticated network of survival strategies governing energy conservation and structural adaptation. By synthesizing heterogeneous transcriptomics, this study reveals robust pathways that are overlooked in single-platform investigations. This work provides a prioritized roadmap for utilizing functional validation and precision breeding to accelerate the development of climate-resilient rice cultivars.