Ex Vivo Human Foreskin Tissue Circumcision via High-Frequency Electric Welding

BACKGROUND: Despite the clinical significance of circumcision, traditional suturing is frequently compromised by intraoperative bleeding and lengthy recovery periods. While high-frequency electric welding (HFEW) presents a compelling alternative, its utility in foreskin removal procedures remains unexplored. METHODS: Employing freshly excised human foreskin tissues, this study simulated the circumcision procedure to benchmark HFEW against standard suturing techniques. Critical performance metrics, encompassing tensile integrity, thermal injury scope, and operative efficiency, were rigorously quantified. RESULTS: < 0.001). However, mechanical testing revealed disparities in tissue adhesion; the HFEW cohort recorded lower forces for initial tearing (4.42 ± 1.02 N) and complete rupture (6.15 ± 1.65 N) compared to the superior tensile resistance of the suturing group (7.91 ± 3.26 N and 14.22 ± 6.91 N, respectively). CONCLUSIONS: Although HFEW yields comparatively lower tensile strength, its remarkable operational efficiency positions it as a viable technical innovation for circumcision. These preliminary findings support the pursuit of further in vivo investigations to confirm its clinical applicability.

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Publication Details

Journal
Bioengineering
Published
2026-03-31
DOI
https://doi.org/10.3390/bioengineering13040411
Primary Topic
Genital Health and Disease
Type
article
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article

Ex Vivo Human Foreskin Tissue Circumcision via High-Frequency Electric Welding

Jiakuan Liu, Chaoying Liu, Caihui Zhu, Kai Fang et al.
Bioengineering
Genital Health and Disease
article

Ex Vivo Human Foreskin Tissue Circumcision via High-Frequency Electric Welding

Jiakuan Liu, Chaoying Liu, Caihui Zhu, Kai Fang, Shengjie Liang, Zhe Hu, Simin Li, J. Y. Qiu, Xin Chen, Yang Li, Dong Liu, Ze-Wen Dong
article en

Abstract

BACKGROUND: Despite the clinical significance of circumcision, traditional suturing is frequently compromised by intraoperative bleeding and lengthy recovery periods. While high-frequency electric welding (HFEW) presents a compelling alternative, its utility in foreskin removal procedures remains unexplored. METHODS: Employing freshly excised human foreskin tissues, this study simulated the circumcision procedure to benchmark HFEW against standard suturing techniques. Critical performance metrics, encompassing tensile integrity, thermal injury scope, and operative efficiency, were rigorously quantified. RESULTS: < 0.001). However, mechanical testing revealed disparities in tissue adhesion; the HFEW cohort recorded lower forces for initial tearing (4.42 ± 1.02 N) and complete rupture (6.15 ± 1.65 N) compared to the superior tensile resistance of the suturing group (7.91 ± 3.26 N and 14.22 ± 6.91 N, respectively). CONCLUSIONS: Although HFEW yields comparatively lower tensile strength, its remarkable operational efficiency positions it as a viable technical innovation for circumcision. These preliminary findings support the pursuit of further in vivo investigations to confirm its clinical applicability.

BioengineeringVol. 13(4)
Fudan University (CN), Pudong Medical Center (CN)
Industry, innovation and infrastructure
Openalex Percentile: Top 38%
Genital Health and Disease
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