NAMPT inhibition induces ferroptosis via mitochondrial metabolic reprogramming to enhance tumour immunogenicity in glioblastoma

Background: salvage pathway, is highly expressed in glioblastoma and represents a promising metabolic target. Methods: immune responses were examined using a prophylactic vaccination model in GL261 glioma-bearing mice. Results: , GMX1778 pre-treatment significantly reduced intracranial tumour incidence and enhanced anti-tumour immune responses in mice. Conclusion: NAMPT inhibition induces ferroptosis via mitochondrial metabolic reprogramming and subsequently enhances tumour immunogenicity through ER stress activation. These findings highlight a novel metabolic-immune mechanism and suggest that NAMPT inhibitors could serve as promising agents for glioblastoma therapy.